ATTENTION
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Please read "Drug Information" before purchase.

Active ingredient
Sacubitril valsartan sodium hydrate

Brand name medicine
ENTRESTO
Effects of this medicine
・This medicine suppresses the actions of substances called neprilysin and angiotensin II to lower blood pressure. It also reduces the amount of water stored in the body, reduces the burden on the heart, and prevents worsening of heart failure.
・It is usually used to treat chronic heart failure and hypertension.
Dosing schedule (How to take this medicine)
・For chronic heart failure:
[for adults] In general, for adults, take 50 mg of sacubitril valsartan at a time, twice a day as the initial dose. The dosage may be increased up to 200 mg at intervals of 2 to 4 weeks in a stepwise manner if the adverse reactions do not interfere with the treatment. ・The dose is 50 mg, 100 mg or 200 mg at a time. The dosage may be adjusted according to the tolerability.
[for children] In general, for children aged 1 year or older, take sacubitril valsartan at the starting dose based on body weight (details are described below) twice daily. If tolerated, the dose may be gradually increased to the target dose at 2 to 4 weeks intervals. The dosage may be adjusted according to tolerability.
=Details of dosage for children (single dose)=
・The starting dose per administration based on body weight is 0.8 mg/kg for under 40 kg, 0.8 mg/kg for 40 kg or over but under 50 kg, and 50 mg for over 50 kg. The first ascending dose will be 1.6 mg/kg for under 40 kg, 50 mg for 40 kg or over but under 50 kg, and 100 mg for over 50 kg. The second ascending dose will be 2.3 mg/kg for under 40 kg, 100 mg for 40 kg or over but under 50 kg, and 150 mg for over 50 kg. The target dose is 3.1 mg/kg for under 40 kg, 150 mg for 40 kg or over but under 50 kg, and 200 mg for over 50 kg.
・The starting dose may be started with the first ascending dose depending on your previous treatment history and condition.
*For Children, prepared syrup (suspension) may be given.
・For hypertension: In general, for adults, take 200 mg of sacubitril valsartan at a time, once a day. The dosage should be adjusted according to the age or symptoms. The maximum dose is up to 400 mg at a time, once a day.
・Each tablet of this medicine contains 200 mg of sacubitril valsartan. In any case, strictly follow the instructions.
・The initial dose may be started at 100 mg once daily for the treatment of hypertension depending on your condition.
・If you miss a dose, take a dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
Before using this medicine, be sure to tell your doctor and pharmacist
・If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines or foods.
・If you have renal artery stenosis, hyperkalemia, cerebrovascular disorder, renal dysfunction, hepatic dysfunction, hypotension, a history of angioedema, or schedule of surgery.
・If you are on hemodialysis or a regimen of low-salt diet.
・If you are pregnant, possibly pregnant or breastfeeding.
・If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Precautions while taking this medicine
・This medicine may cause dizziness or lightheadedness. Pay close attention when you work at heights, drive a car or operate machinery.
・This medicine has been reported to be teratogenic (may cause malformations in fetuses), women of childbearing potential should avoid pregnancy by using a reliable contraceptive method while using this medicine and for 1 week after the discontinuation of this medicine. So if you suspect that you are pregnant, contact your doctor immediately.
・It is recommended not to breastfeed while taking this medicine. If you are breastfeeding, consult with your doctor.
・For healthcare professional use only
Storage conditions and other information
・Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
・Discard the remainder. Do not store them. If you are not sure how to discard, consult with your pharmacist or medical institution. Do not give it to anyone else.