Cleaved-Notch1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BZ16348-50, BZ16348-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: P46531

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB,ICC/IF,IHC-F,IHC-P,ELISA

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000

Background: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Cleaved-Notch1 in variousLysates using Cleaved-Notch1 antibody.

Bioworld Molecular Weight: Calculated MW: 273 kDa; Observed MW: 110 kDa

Specificity: IgG

Alternative Name: NOTCH1; TAN1; Neurogenic locus notch homolog protein 1; Notch 1; hN1; Translocation-associated notch protein TAN-1

Immunogen: The antiserum was produced against synthesized peptide derived from human Notch 1. AA range:1735-1784

Conjugate: Unconjugated

Modification: Cleaved