QPX7728 is a potent, ultra-broad-spectrum boronic acid beta-lactamase inhibitor. QPX7728 inhibits key serine and metallo beta-lactamases at a nano molar range.

Product information

CAS Number: 2170834-63-4

Molecular Weight: 221.98

Formula: C10H8BFO4

Chemical Name: (2S,4R)-9-fluoro-5-hydroxy-6-oxa-5-boratricyclo[5.4.0.0²,⁴]undeca-1(7),8,10-triene-8-carboxylic acid

Smiles: OC(=O)C1=C(F)C=CC2[C@H]3C[C@H]3B(O)OC=21

InChiKey: KOHUFVUIYUCFNG-PHDIDXHHSA-N

InChi: InChI=1S/C10H8BFO4/c12-7-2-1-4-5-3-6(5)11(15)16-9(4)8(7)10(13)14/h1-2,5-6,15H,3H2,(H,13,14)/t5-,6-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

QPX7728 is a potent inhibitor of Class D carbapenemases from A. baumannii. QPX7728 is minimally affected by the activity of major MDR efflux pumps from P. aeruginosa, representing a significant improvement over the earlier generation boronate beta-lactamase inhibitor (BLI) vaborbactam. The ultra-broad-spectrum beta-lactamase inhibition profile combined with enhancement of the activity of multiple beta-lactam antibiotics with varying sensitivity to the intrinsic resistance mechanisms of efflux and permeability indicate QPX7728 is a useful inhibitor for use with multiple beta-lactam antibiotics.

Products are for research use only. Not for human use.