LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively.

Product information

CAS Number: 770688-66-9

Molecular Weight: 398.45

Formula: C23H24F2N2O2

Chemical Name: 4-{[4,4-bis(4-fluorophenyl)butyl]amino}-2,3,4,5,6,7-hexahydro-1,2-benzoxazol-3-one

Smiles: O=C1NOC2CCCC(NCCCC(C3C=CC(F)=CC=3)C3C=CC(F)=CC=3)C=21

InChiKey: QOSIKKDOOCQXMT-UHFFFAOYSA-N

InChi: InChI=1S/C23H24F2N2O2/c24-17-10-6-15(7-11-17)19(16-8-12-18(25)13-9-16)3-2-14-26-20-4-1-5-21-22(20)23(28)27-29-21/h6-13,19-20,26H,1-5,14H2,(H,27,28)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

LU-32-176B (i.p.) and EF1502 can prevent sound-induced seizures in the Frings AGS-susceptible mouse model.

Products are for research use only. Not for human use.